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Intoleranta la histamina apare in urma unui dezechilibru, la nivelul organismului, intre procesele de producere si degradare a histaminei. Motivul pentru care acest fenomen se intampla este datorat unui nivel scazut al。

Histamina este o amină biogenă prezentă în cantităţi variabile în multe alimente. În mod normal histamina alimentară este rapid detoxifiată de către aminoxidaze; persoanelehistamina in sange care prezintă o activitate redusă a acestor enzime au risc de a。

Histamina determina cresterea permeabilitatii vaselor de sange care permite celulelor imune si altor substante sa migreze prin peretele vasului din circulatia sanguina in locul afectat.

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